Centre for Human Reproductive Science
In the natural conception process millions of sperm are selected down to tens or hundreds reaching the egg, how this occurs and what may allow the best sperm to be selected or others to be removed are also key questions for assisted conception treatment.
Data from many labs around the world suggests that certain factors in diet may affect sperm quality. Our team are particularly interested not just in whether we can improve male fertility, but whether changes have improved health implications for the children born afterwards
HABSelect was a multicentre randomised blinded controlled trial, designed to test a sperm selection method which may increase the number of live births and reduce miscarriage rates
WHAT WE DO
The Centre for Human Reproductive Science (ChRS) is a Human Fertilisation and Embryology Authority (HFEA) licenced research centre, established in December 2006 to further develop research and innovation in fertility diagnosis and treatment.
The ChRS team have made advances in various areas, these include achievements in:
- Translational medicine, such as the invention of the male Fertell over-the-counter home fertility test.
- The first detailed studies of ion channels in human sperm.
- Detailed characterisation of the events occurring in sperm in response to steroid hormones, including the discovery of slow calcium oscillations, now thought to possibly regulate to how sperm swim. To date the identity of the cell receptors involved has not been clearly understood.
- Substantial follow-up data of children born through IVF treatment to check for increased risks associated with the treatment.
- ChRS also has psychology collaborations to actively pursue research enabling better understanding of patient feelings and care during fertility treatment; and issues surrounding motivation to be a donor and receipt of donor gametes.
The ChRS does not directly enter into patient treatment or diagnosis being focussed upon research.
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